Apolipoprotein A-II is atheroprotective

Apolipoprotein A-II, a component of high-density lipoprotein (HDL), was shown to be anti-atherogenic in one of the largest studies to date, based on the EPIC-Norfolk cohort. HDL Forum Editor0 Professor Kerry-Anne Rye discusses these data and their implications.
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Raising high density lipoprotein: need to take account of functionality?

Are very high levels of high-density lipoprotein (HDL) cholesterol and very large HDL particles associated with increased coronary risk? These are the findings from an analysis of data from the IDEAL (Incremental Decrease in End Points through Aggressive Lipid Lowering) trial and EPIC (European Prospective Information into Cancer and Nutrition) Norfolk Cohort, discussed by HDL Forum Editor Professor Kerry-Anne Rye. The analysis was published in the Journal of the American College of Cardiology on 5 February 2008.
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Statin therapy does not eliminate cardiovascular risk due to low high density lipoprotein cholesterol in diabetes patients

HDL Forum Editor Dr Anthony Wierzbicki discusses findings from a new meta-analysis from the Cholesterol Treatment Trialists' (CTT) Collaborators, published in The Lancet, January 11, 2008. Diabetes patients with a low level of high density lipoprotein (HDL) cholesterol remain at increased cardiovascular risk, despite statin therapy.
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Anacetrapib, a new CETP inhibitor, raises high-density lipoprotein (HDL) cholesterol without affecting blood pressure

HDL Forum Editor Professor Philip Barter discusses new data on anacetrapib, a cholesteryl ester transfer protein (CETP) inhibitor published by Rajesh Krishna and co-workers in The Lancet, December 2007.
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New data support the use of total/HDL cholesterol ratio to assess stroke risk

HDL Forum Editor Professor M John Chapman discusses a recent meta-analysis on cholesterol and vascular risk, published by the Prospective Studies Collaboration, Oxford, in The Lancet, December 1, 2007.
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Meta-analysis supports raising high-density lipoprotein (HDL) cholesterol

HDL Forum Editor Professor Philip Barter highlights findings from a meta-analysis of interventions for raising high-density lipoprotein (HDL) cholesterol by IM Singh and researchers, published in the Journal of the American Medical Association.
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Changes in apolipoprotein A-I impair its antiatherogenic function

HDL Forum Editor Professor Kerry-Anne Rye discusses experimental data from a study by A Hoang and co-workers, published in Diabetologia. These data suggest that modification of apolipoprotein A-I (apoA-I), the main apolipoprotein in high-density lipoprotein (HDL), can impair its antiatherogenic function and contribute to increased cardiovascular risk.
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Raising high-density lipoprotein (HDL) cholesterol in patients at LDL goal: new study

HDL Forum Editor Professor Philip Barter comments on an interesting and important new lipid trial in patients with persistently low levels of high-density lipoprotein (HDL) cholesterol: Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol-6-HDL and LDL Treatment Strategies in Atherosclerosis (ARBITER 6-HALTS).
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Low level of high-density lipoprotein (HDL) cholesterol predictive of outcome after cardiac stenting

HDL Forum Editor Professor John Chapman comments on evidence that a low level of high-density lipoprotein (HDL) cholesterol is an independent predictor of long-term outcome after cardiac stenting. The study was published in Thrombosis and Haemostasis.
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Low high-density lipoprotein (HDL) cholesterol linked to abnormal sleep

HDL Forum Editor Professor John Chapman notes interesting data from the Nurses' Health Study which support an association between low high-density lipoprotein (HDL) cholesterol and abnormalities in sleep habits. The analysis was reported in Diabetes Care.
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Regular aerobic exercise increases high-density lipoprotein (HDL) cholesterol

HDL Forum Editor Professor Philip Barter highlights a meta-analysis by S Kodama and co-workers which confirms the benefit of regular aerobic exercise on raising high-density lipoprotein (HDL) cholesterol. These data re-enforce recommendations for increasing levels of activity as a cardioprotective strategy. The analysis was reported in Archives of Internal Medicine.
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Antiatherogenic effects of high-density lipoprotein (HDL) cholesterol during the perimenopause

HDL Forum Editor Professor Philip Barter comments on findings suggesting that the antiatherogenic effects of high-density lipoprotein (HDL) cholesterol may decrease around the age of menopause. These results from the Los Angeles Atherosclerosis Study were published on-line in Atherosclerosis.
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Defective ABCA1 increases coronary risk in familial low high-density lipoprotein (HDL) cholesterol

HDL Forum Editor Professor Kerry-Anne Rye discusses a study investigating the relationship between familial low high-density lipoprotein (HDL) cholesterol, coronary risk and ABCA1, reported by A Soro-Paavonen and co-workers in the Journal of Lipid Research.
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High-density lipoprotein (HDL) protects against atherosclerosis by upregulation of anti-inflammatory and anti-oxidant pathways

HDL Forum Editor Professor Kerry-Anne Rye highlights new data suggesting an additional mechanism by which high-density lipoprotein (HDL) protects against atherosclerosis, reported by NM Gharavi and co-workers in Arteriosclerosis, Thrombosis and Vascular Biology.
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